Sorafenib
Everything that changed this flow. Back to the flow
79e396a5-6625-428c-98b1-235b2d2aa06f
By field
13 fields| Field | Changes | Written by | Latest note |
|---|---|---|---|
| properties | 5 | enrich_references, normalise_property_values, opsin_iupac, rdkit_post_consensus, rdkit_pre_consensus | typed the way the ontology types it |
| altLabel | 4 | chebi_altlabels, consensus_match, dedupe_altlabels | Deduplicated altLabel values and removed entries matching prefLabel |
| prefLabel | 2 | bootstrap_labels, consensus_match | cas=284461-73-0; cc_chebi_agreed_name='Sorafenib'; object_uuid=fo-505e326e41db0eed |
| cas_match_labels | 1 | consensus_match | group_key=4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-n-methyl-2-pyridinecarboxamide||dimension=Environmental > media=Ground > geography=Non-agricultural; group_sources=['chebi', 'pubchem']; cas_sources={'284461-73-0': ['chebi', 'pubchem']}; assigned CAS labels from group consensus; object_uuid=fo-505e326e41db0eed: {'284461-73-0': 'exactMatch'} |
| concept_associations | 1 | carry_associations_onto_flows | associations resolved on the elementary layer |
| context | 1 | default_context_mapping | Mapped from context mapping for source=EF 3.1, source context Emissions > Emissions to water > Emissions to water, unspecified |
| context_iri | 1 | default_context_mapping | Mapped from context mapping for source=EF 3.1, source context Emissions > Emissions to water > Emissions to water, unspecified |
| name | 1 | bootstrap_labels | Purged legacy name field to enforce prefLabel usage |
| references | 1 | enrich_references | Added references with provenance; cas_numbers=['284461-73-0']; matched_chebi_ids=['http://purl.obolibrary.org/obo/CHEBI_50924']; candidate_pubchem_cids=[216239, 406563, 25191001]; selected_pubchem_cids=[216239]; formula_similarity_expected=[]; pubchem_selection_rule=curated_cas_then_formula_similarity_then_prefer_chebi_aligned_when_unambiguous_else_keep_all_cas_matches; single_cas_commonchem_link=yes |
| skos_definition | 1 | enrich_references | Merged ChEBI/PubChem definitions into skos:definition |
| synonyms | 1 | bootstrap_labels | Removed legacy synonyms field in favor of structured labels |
| types | 1 | link_flows_to_their_substance | the substance's answer, copied onto its flow |
| unit_iri | 1 | unit_normalization | Unit IRI set from normalization of 'kg' |
Where several steps wrote one field, the last one won — and the log below shows the sequence.
Changes
21| # | Step | Field | From | To | Why |
|---|---|---|---|---|---|
| 1,510 | bootstrap_labels | prefLabel | — | [{"@value":"4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-n-methyl-2-pyridinecarboxamide","… | Bootstrapped prefLabel from legacy name field |
| 1,511 | bootstrap_labels | name | 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-n-methyl-2-pyridinecarboxamide | — | Purged legacy name field to enforce prefLabel usage |
| 1,512 | bootstrap_labels | synonyms | ["2-pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-n-methyl-","sorafenib… | [] | Removed legacy synonyms field in favor of structured labels |
| 122,264 | default_context_mapping | context | — | {"dimension":"Environmental","media":"Water","water_body":"Unknown"} | Mapped from context mapping for source=EF 3.1, source context Emissions > Emissions to water > Emissions to water, unspecified |
| 122,265 | default_context_mapping | context_iri | — | https://vocab.brightway.one/flow-contexts/envi-wate-unkn | Mapped from context mapping for source=EF 3.1, source context Emissions > Emissions to water > Emissions to water, unspecified |
| 213,839 | unit_normalization | unit_iri | — | https://vocab.brightway.one/units/unit/KiloGM | Unit IRI set from normalization of 'kg' |
| 228,628 | enrich_references | properties | {} | {"https://w3id.org/chemrof/molecular_formula":{"@id":"https://w3id.org/chemrof/molecular_formula","@value":["C21H16ClF3… | Added ChEBI/PubChem properties (chebi_ids=1, pubchem_cids=1) |
| 228,629 | enrich_references | skos_definition | — | [{"@value":"A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chlor… | Merged ChEBI/PubChem definitions into skos:definition |
| 228,630 | enrich_references | references | [] | [{"@id":"drugcentral:2459","provenance":{"prov:wasGeneratedBy":"enrich_references.chebi_xrefs","prov:wasAttributedTo":"… | Added references with provenance; cas_numbers=['284461-73-0']; matched_chebi_ids=['http://purl.obolibrary.org/obo/CHEBI_50924']; candidate_pubchem_cids=[216239, 406563, 25191001]; selected_pubchem_cids=[216239]; formula_similarity_expected=[]; pubchem_selection_rule=curated_cas_then_formula_similarity_then_prefer_chebi_aligned_when_unambiguous_else_keep_all_cas_matches; single_cas_commonchem_link=yes |
| 248,733 | rdkit_pre_consensus | properties | {"https://w3id.org/chemrof/molecular_formula":{"@id":"https://w3id.org/chemrof/molecular_formula","@value":["C21H16ClF3… | {"https://w3id.org/chemrof/molecular_formula":{"@id":"https://w3id.org/chemrof/molecular_formula","@value":["C21H16ClF3… | rdkit_pre_consensus from 'CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F'; added: monoisotopic_mass |
| 254,554 | chebi_altlabels | altLabel | [] | [{"@value":"4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide","@langu… | Added 4 ChEBI synonym(s) as altLabel from 1 linked ChEBI record(s) |
| 262,457 | consensus_match | prefLabel | [{"@value":"4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-n-methyl-2-pyridinecarboxamide","… | [{"@value":"Sorafenib","@language":"en","source":{"prov:wasGeneratedBy":"consensus_match","prov:wasAttributedTo":"conse… | cas=284461-73-0; cc_chebi_agreed_name='Sorafenib'; object_uuid=fo-505e326e41db0eed |
| 262,458 | consensus_match | altLabel | [{"@value":"4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide","@langu… | [{"@value":"4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide","@langu… | cas=284461-73-0; added original name as altLabel after CC/ChEBI rename; object_uuid=fo-505e326e41db0eed |
| 262,459 | consensus_match | altLabel | [{"@value":"4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide","@langu… | [{"@value":"4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide","@langu… | group_key=4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-n-methyl-2-pyridinecarboxamide||dimension=Environmental > media=Ground > geography=Non-agricultural; cas=284461-73-0; added Common Chemistry CAS names as altLabel: 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-<em>N</em>-methyl-, 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-<em>N</em>-methyl-2-pyridinecarboxamide, <em>N</em>-[4-Chloro-3-(trifluoromethyl)phenyl]-<em>N</em>′-[4-[2-(<em>N</em>-methylcarbamoyl)-4-pyridyloxy]phenyl]urea, BAY 43-9006, Nevaxar; object_uuid=fo-505e326e41db0eed |
| 262,460 | consensus_match | cas_match_labels | — | {"284461-73-0":"exactMatch"} | group_key=4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-n-methyl-2-pyridinecarboxamide||dimension=Environmental > media=Ground > geography=Non-agricultural; group_sources=['chebi', 'pubchem']; cas_sources={'284461-73-0': ['chebi', 'pubchem']}; assigned CAS labels from group consensus; object_uuid=fo-505e326e41db0eed: {'284461-73-0': 'exactMatch'} |
| 273,853 | opsin_iupac | properties | {"https://w3id.org/chemrof/molecular_formula":{"@id":"https://w3id.org/chemrof/molecular_formula","@value":["C21H16ClF3… | {"https://w3id.org/chemrof/molecular_formula":{"@id":"https://w3id.org/chemrof/molecular_formula","@value":["C21H16ClF3… | opsin_iupac: set authoritative IUPAC name, SMILES, InChI from '4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide' |
| 280,242 | rdkit_post_consensus | properties | {"https://w3id.org/chemrof/molecular_formula":{"@id":"https://w3id.org/chemrof/molecular_formula","@value":["C21H16ClF3… | {"https://w3id.org/chemrof/molecular_formula":{"@id":"https://w3id.org/chemrof/molecular_formula","@value":["C21H16ClF3… | rdkit_post_consensus from 'CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1'; confirmed: smiles_string, inchi2d_string, inchi2d_key_string, molecular_formula, molecular_mass, monoisotopic_mass |
| 292,027 | dedupe_altlabels | altLabel | [{"@value":"4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide","@langu… | [{"@value":"4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide","@langu… | Deduplicated altLabel values and removed entries matching prefLabel |
| 342,123 | carry_associations_onto_flows | concept_associations | [] | [{"@type":"xkos:ConceptAssociation","xkos:sourceConcept":{"@id":"https://vocab.brightway.one/ef/3.1/flow/79e396a5-6625-… | associations resolved on the elementary layer |
| 388,136 | normalise_property_values | properties | {"https://w3id.org/chemrof/molecular_formula":{"@id":"https://w3id.org/chemrof/molecular_formula","@value":["C21H16ClF3… | {"https://w3id.org/chemrof/molecular_formula":{"@id":"https://w3id.org/chemrof/molecular_formula","@value":["C21H16ClF3… | typed the way the ontology types it |
| 394,749 | link_flows_to_their_substance | types | — | ["https://w3id.org/chemrof/NeutralMolecule"] | the substance's answer, copied onto its flow |
PROV-O trail
21 activitiesOne activity per change: which version of the flow it consumed, and which it produced. The values are on the change with the same number — stored once, not twice.
| Activity | Field | Agent | Used | Generated |
|---|---|---|---|---|
| ef:activity/change/20260820T1812399309960000/1510 | prefLabel | ef:agent/bootstrap_labels | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v0 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v1 |
| ef:activity/change/20260820T1812399309960000/1511 | name | ef:agent/bootstrap_labels | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v1 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v2 |
| ef:activity/change/20260820T1812399309960000/1512 | synonyms | ef:agent/bootstrap_labels | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v2 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v3 |
| ef:activity/change/20260820T1812399309960000/122264 | context | ef:agent/default_context_mapping | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v3 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v4 |
| ef:activity/change/20260820T1812399309960000/122265 | context_iri | ef:agent/default_context_mapping | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v4 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v5 |
| ef:activity/change/20260820T1812399309960000/213839 | unit_iri | ef:agent/unit_normalization | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v5 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v6 |
| ef:activity/change/20260820T1812399309960000/228628 | properties | ef:agent/enrich_references | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v6 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v7 |
| ef:activity/change/20260820T1812399309960000/228629 | skos_definition | ef:agent/enrich_references | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v7 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v8 |
| ef:activity/change/20260820T1812399309960000/228630 | references | ef:agent/enrich_references | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v8 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v9 |
| ef:activity/change/20260820T1812399309960000/248733 | properties | ef:agent/rdkit_pre_consensus | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v9 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v10 |
| ef:activity/change/20260820T1812399309960000/254554 | altLabel | ef:agent/chebi_altlabels | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v10 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v11 |
| ef:activity/change/20260820T1812399309960000/262457 | prefLabel | ef:agent/consensus_match | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v11 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v12 |
| ef:activity/change/20260820T1812399309960000/262458 | altLabel | ef:agent/consensus_match | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v12 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v13 |
| ef:activity/change/20260820T1812399309960000/262459 | altLabel | ef:agent/consensus_match | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v13 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v14 |
| ef:activity/change/20260820T1812399309960000/262460 | cas_match_labels | ef:agent/consensus_match | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v14 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v15 |
| ef:activity/change/20260820T1812399309960000/273853 | properties | ef:agent/opsin_iupac | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v15 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v16 |
| ef:activity/change/20260820T1812399309960000/280242 | properties | ef:agent/rdkit_post_consensus | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v16 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v17 |
| ef:activity/change/20260820T1812399309960000/292027 | altLabel | ef:agent/dedupe_altlabels | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v17 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v18 |
| ef:activity/change/20260820T1812399309960000/342123 | concept_associations | ef:agent/carry_associations_onto_flows | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v18 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v19 |
| ef:activity/change/20260820T1812399309960000/388136 | properties | ef:agent/normalise_property_values | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v19 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v20 |
| ef:activity/change/20260820T1812399309960000/394749 | types | ef:agent/link_flows_to_their_substance | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v20 | ef:flow/79e396a5-6625-428c-98b1-235b2d2aa06f/v21 |